How LBG is responding to COVID-19 differently? Much of the world is beginning to see a decline in COVID-19 cases but for Sub-Saharan Africa the virus infection is just getting started. Literacy Bridge Ghana (LBG) since the outbreak of COVID-19 in Ghana has been collaborating with Ghana Health Service (GHS) and Amplio Network-USA to reduce the spread of the disease. In Northern Ghana where this response is currently happening, we are mitigating the spread of the disease in resource poor settings by making available lifesaving information on how vulnerable people can stay safe through GHS existing local level structures—community based health planning and services (CHPS) compounds and community health volunteers. Our solution–the AmplioTalking Book has made it possible to reach the most vulnerable people in rural communities with information in their preferred languages on COVID-19 where it would have been challenging to achieve due to poor media coverage, poor access to electricity, lack of internet and availability of experts to deliver awareness messages in the local languages. LBG’s COVID-19 response is originally planned to last for 3 months (April-June 2020) but could be extended depending on availability of funds and the COVID-19 situation in the country at the end of the current phase of the response. The LBG COVID-19 awareness campaign is delivered through 207 CHPS compounds and 73 community health volunteers across 8 selected vulnerable districts of the Upper West region (Wa West, Nadowli-Kaleo, Jirapa, Lawra, Nandom, Lambusie-Kane, Sissala West and Sissala East). Over the response period, we will reach about 168,000 vulnerable people with messages on how they can protect themselves and their families from contracting COVID-19 and consequently increase their capacity to take lifesaving decisions that keep them safe from the spread of the disease. What are the Next steps for LBG in COVID-19 response? LBG is actively looking for additional funding to prolong our current response in 8 districts in the Upper West region and extend to the remaining 3 districts in the region (Wa, Wa East and Daffiama-Bussie-Issah) including 3 selected vulnerable districts in Northern region (Savelugu, Tolon and Karaga).